A Comparative Study of Dothiepin (prothiaden) and Imipramine in Depression
نویسندگان
چکیده
In a single-blind, randomised, parallel-group study comparing the efficacy and tolerability of dothiepin (50-150 mg per day) and imipramine (50-150 mg per day) for 6 weeks, involving 60 adult patients with depression, it was observed that dothiepin was comparable to imipramine in terms of efficacy as assessed by Hamilton Rating Scale for depress ion, global scale for severty of illness and clinician's overall assessment of efficacy. Dothiepin was found to have a significantly earlier onset of anxiolytic action compared to imipramine. Dothiepin was well tolerated.
منابع مشابه
A Comparative Evaluation of Dothiepin (prothieden) and Imipramine
A double-blind controlled comparative trial of Dothiepin was carried out in Psychiatric Hospital, for comparing its efficacy with that of Imipramine, in the treatment of depression and also to compare the incidence and severity of side effects of the two drug;. Dothicpin hydrochloride is a tricyclic anti-depressant drug with pharmacological properties common to Imipramine Amitryptline and relat...
متن کاملA Comparison of a Divided and a Single Dose Regime of Dothiepin and Its Therapeutic Efficacy
In a double-blind study the advantages of a once-a-day dosage of a tricyclic antidepressant as against a thrice daily dosage regimen was evaluated using dothiepin (Prothiaden) and matching placebo tablets. Twenty eight adult patients of both sexes participated in the study and were randomly allocated to drug treatment. Out of 28 patients who received dothiepin, 17 showed good improvement, in 6 ...
متن کاملAn exceptional reaction to dothiepin (prothiaden).
Dothiepin (prothiaden) is a tricyclic antidepressant related to amitryptylline. Pharma¬ cologically each 25 mg dose is the equivalent to 22-2 mg of 11.(3 dimethylamino propylidene) 6-11.dehydrodibenythiepin. While used for some ten years in Europe, many of the reports are Austro-CzechovakiaPolish in origin, it is still relatively new in this country. The formulation makes its anti¬ depressant p...
متن کاملTheoretical study of inclusion complexation of tricylic antidepressant drugs with β-cyclodextrin
The inclusion process of four tricyclic antidepressant drugs (carbamazepine, imipramine, dothiepin and doxepin) with β-cyclodextrin (β-CD), as well as their possible interaction types have been investigated theoretically. The data suggest that these drugs are partially encapsulated into the β-CD cavity. The formation of the inclusion complex is predicted to be an enthalpy-driven process in gas ...
متن کاملMeta-analysis of the reversible inhibitors of monoamine oxidase type A moclobemide and brofaromine for the treatment of depression
Specific interventions included in the review Studies of RIMAs, i.e. MOC (18 to 600 mg) or BRO (93.1 to 150 mg/day) versus either placebo or another standard tricyclic antidepressant, selective serotonin re-uptake inhibitor (SSRI) or other class of antidepressant, were included. The active comparison groups included: diazepam, tranylcypromine, mianserin, isocarboxide, imipramine, amitriptyline,...
متن کامل